CENTER-TBI Core Study
CENTER-TBI aims to advance the care for patients with traumatic brain injury (TBI), a field in medicine with one of the greatest unmet needs. It is a large-scale project (FP7 grant 602150) aiming to improve characterization of TBI in order to facilitate individualized treatments and identify the most effective clinical care, providing high quality evidence in support of treatment recommendations and guidelines.
The CENTER-TBI Core study collected high quality clinical and epidemiological data with repositories for neuro-imaging, DNA, and serum from over 4500 patients with TBI in 19 countries in Europe and Israel. Enrolment was in three strata, differentiated by care path: (1) patients discharged home from the emergency room (ER stratum); (2) patients admitted to hospital, but not to the intensive care unit (admission stratum); (3) patients admitted to the Intensive Care Unit (ICU stratum). It includes long-term outcome up to 24 months after injury.
- Supplementary Information
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For more information on the study, visit the CENTER-TBI website.
The CENTER-TBI team developed Frequency Tables for the CENTER-TBI data. These Frequency Tables do not lend themselves to analyses of the CENTER-TBI data, but serve to provide some orientating insight into the availability and distribution of data in the CENTER-TBI dataset. The Frequency Tables are available here.
Visit CENTER-TBI Core
Design
- Follow Up
- Follow up assessments at 2wk, 3 months, 6 months, 12 months and 24 months depending on the type of patient and inclusion in extended studies
- Supplementary Information
- Extended studies: Selected sites, meeting additional logistic requirements, will participate in extended data collection with regard to MR imaging; Extended coagulation and biomarker studies; Acquisition of high resolution ICU monitoring data.
Number of participants
- Number of participants
- 4,509
- Number of participants with biosamples
- 3,803
Access
Available on request
| Data | |
| Biosamples | |
| CT/MRI scans and HR ICU meta data |
Availability of access information
On the study website : https://www.center-tbi.eu/
Timeline
TBI patients CENTER-TBI Core
Patients that presented to the hospital with Traumatic Brain Injury within 24 hours after injury.
Selection Criteria
- Countries
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- Finland
- Norway
- Sweden
- Netherlands
- Belgium
- Denmark
- Germany
- United Kingdom
- Spain
- France
- Switzerland
- Austria
- Lithuania
- Latvia
- Hungary
- Serbia
- Romania
- Italy
- Israel
- Health Status
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- Other criteria
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Inclusion Criteria:
- Clinical diagnosis of TBI
- Clinical indication for CT scan
Exclusion Criteria:
- Severe pre-existing neurological disorder that would confound outcome assessments
Recruitment
- Sources of recruitment
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- Specific population
- Specific Population
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- Hospital patients with TBI
Number of participants
- Number of participants
- 4,509
- Number of participants with biosamples
- 3803
- Supplementary Information
Data Collection Event
- Start Date
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2014-12
- End Date
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2017-12
- Data sources
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- Acute care data
- Cognitive measures
- Imaging
- Biomarkers
- Questionnaires